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Network analysis of liver transcripts post <t>pig</t> <t>CSF1-Fc</t> treatment. Expression data for mouse livers +/- CSF1-Fc ( n = 3) was analyzed alongside that of <t>BMDM</t> expression data (+/- LPS). ( a ) A network graph of transcript-to-transcript Pearson correlation relationships was filtered to show relationships of r ≥ 0.96, resulting in a graph of 2,555 nodes (transcripts) connected by 265,108 edges (Pearson correlation relationships). The graph was then clustered using the MCL clustering algorithm into groups of co-expressed genes. Nodes with the same color belong to the same cluster of co-expressed genes and tend to be highly connected within the network. ( b ) Expression data for five clusters with each point on the graph representing an individual mouse.
Bmdm Data, supplied by Partek, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Network analysis of liver transcripts post pig CSF1-Fc treatment. Expression data for mouse livers +/- CSF1-Fc ( n = 3) was analyzed alongside that of BMDM expression data (+/- LPS). ( a ) A network graph of transcript-to-transcript Pearson correlation relationships was filtered to show relationships of r ≥ 0.96, resulting in a graph of 2,555 nodes (transcripts) connected by 265,108 edges (Pearson correlation relationships). The graph was then clustered using the MCL clustering algorithm into groups of co-expressed genes. Nodes with the same color belong to the same cluster of co-expressed genes and tend to be highly connected within the network. ( b ) Expression data for five clusters with each point on the graph representing an individual mouse.

Journal: Molecular Therapy

Article Title: Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor

doi: 10.1038/mt.2014.112

Figure Lengend Snippet: Network analysis of liver transcripts post pig CSF1-Fc treatment. Expression data for mouse livers +/- CSF1-Fc ( n = 3) was analyzed alongside that of BMDM expression data (+/- LPS). ( a ) A network graph of transcript-to-transcript Pearson correlation relationships was filtered to show relationships of r ≥ 0.96, resulting in a graph of 2,555 nodes (transcripts) connected by 265,108 edges (Pearson correlation relationships). The graph was then clustered using the MCL clustering algorithm into groups of co-expressed genes. Nodes with the same color belong to the same cluster of co-expressed genes and tend to be highly connected within the network. ( b ) Expression data for five clusters with each point on the graph representing an individual mouse.

Article Snippet: Partek Inc.) Expression data from the liver +/− CSF1-Fc study was analyzed alongside that of BMDM data generated from the same strain of mice (C57BL/6) (see BMDM method below).

Techniques: Expressing